High vaccination uptake has led to good coverage among those at higher risk, with an estimated vaccine effectiveness of 84% for one dose, and no hospitalizations among vaccinated cases in 2023.
Increased awareness of serostatus, higher rates of serosorting, and a reduction in HIV transmission rates among MSM who engage in seroadaptive behaviors, particularly in the context of PrEP and TasP.
Despite challenges, there was a noted increase in sexual behaviors from April to June, indicating a potential return to previous patterns of sexual activity among MSM after initial reductions during the early pandemic.
The intervention aims to increase engagement in PrEP education and initiation, with preliminary evidence suggesting improved intentions to use PrEP and actual initiation rates among participants in the pilot study.
The study found that individuals with access to PrEP had a relative risk of HIV of 0.52, those who initiated but were not adherent had a risk of 0.48, and those who were adherent had a risk of 0.23 compared to those who did not initiate PrEP, indicating significant protective effects of PrEP.
The study found that 19.7% of participants had received mpox vaccination, and independent risk factors for mpox diagnosis included HIV-PrEP use and having multiple sexual partners. The findings support the refinement of vaccination eligibility criteria to better target at-risk populations.
TT was associated with increased lobular atrophy and decreased amounts of breast epithelium and stroma, suggesting a potential reduction in breast cancer risk for TMIs.
The study predicts that maintaining ART and viral suppression can mitigate the adverse effects of COVID-19 on HIV transmission and control, with a potential overall decrease in new infections over one year (3-17%).
The study found no increase in the number of casual sex partners or condomless anal sex acts over four years of PrEP use. STI incidence remained high but stable, with a slight decrease in chlamydia and gonorrhea among daily PrEP users. Only two daily PrEP users were diagnosed with HIV during the first year on PrEP.
Participants reported significant reductions in anxiety symptoms, internalized prejudice, and depression symptoms, particularly those with lower coping self-efficacy.
Men prioritized ART despite challenges, and those who managed to stay in care reported better health outcomes. The study suggests that improved access to ART services and support could enhance retention for mobile men.
The study found that MSM with indications for PrEP were about three times more likely to be using it compared to those without indications. However, there was a significant proportion of indicated MSM who were not using PrEP, indicating a gap in prevention efforts.
Increased awareness and knowledge of PrEP can lead to higher uptake and adherence, ultimately reducing HIV incidence among at-risk populations.
The study found that 81.5% of respondents were willing to accept vaccination, with higher acceptance rates among those eligible for vaccination (85.2%). Positive beliefs about the vaccine's effectiveness and perceived social norms regarding vaccination contributed to this willingness.
The combined interventions averted 46%-58% of mpox cases, with early vaccination having the largest impact, preventing 21%-39% of infections depending on the city.
High usability of self-testing kits (89.6% on a 0-100 scale) was reported, with participants appreciating the privacy and convenience compared to traditional testing methods.
Identification of high-risk behaviors associated with polysubstance use, leading to targeted interventions to reduce HIV transmission risk.
The interventions resulted in a reduction of new infections by 0.2-4.2% and an increase in quality-adjusted life years (QALYs) by 0.0045-0.24%. The combination strategy of adherence and initiation was found to be cost-effective with an incremental cost-effectiveness ratio of $86,927/QALY gained.
Improved understanding of the distinct characteristics and needs of MSM-IDU and PWID-MSM, leading to more effective prevention strategies for HIV and HCV.
The primary outcome is six-month retention in ART care, with secondary outcomes including cost-effectiveness and improved engagement in HIV treatment programs among men.
The intervention led to a statistically significant increase in the odds of recent HIV testing among MSM and TSM, even among those who did not directly participate in the intervention, indicating a community-wide impact.
Increased access to care, improved sexual health outcomes, and enhanced comfort in seeking help among LGBTQI+ youth.
Positive outcomes include improved sexual health behaviors such as increased HIV testing, consistent condom use, and adherence to PrEP/ART, driven by enhanced intrinsic motivation and needs satisfaction.
Increased awareness, belief, and understanding of U=U; improved risk perception; higher likelihood of HIV testing among HIV negative men.
The study found that 73% of participants were aware of PrEP, and 96% expressed a strong willingness to use it, indicating a positive outlook for PrEP implementation among Rwandan MSM.
The study found that MSM who experienced sexual violence were more likely to use PrEP than those who did not, indicating a potential positive outcome in HIV prevention efforts for this vulnerable population.
The 2wT intervention resulted in an 80% retention rate at 12 months post-ART initiation, compared to 67% in the standard of care group. It also demonstrated potential cost savings if scaled up to a larger population.
Participants reported routine use of HIVST for sexual health, psychological comfort, and a sense of responsibility towards partners, highlighting the importance of community engagement.
The expected outcome is a co-produced intervention and program theory that is suitable for testing in a future feasibility study, potentially leading to improved STI management and reduced transmission among MSM.
The intervention aims to increase the likelihood of GBMSM notifying their one-off partners about STI exposure, thereby improving contact tracing and reducing STI transmission rates.
The implementation of combined case-based and population-based test-and-treat strategies significantly enhances the probability of eliminating emergent XDR strains and reduces outbreak size compared to current practices.
The HIVST method resulted in a higher number of tests distributed and a greater engagement in testing among MSM, with 75% of indexes distributing tests to friends or partners compared to 29% in the testing card arm.
The intervention led to statistically significant reductions in clinically significant depressive and anxiety symptoms, as well as increases in COVID-19 protective behaviors among participants.
Higher perceived risk, knowledge of partner's HIV status, and STI diagnosis were associated with increased likelihood of HIV testing among MSM.
The study found that HRA uptake was higher among participants with a history of anal cytology and lower among those preferring versatile anal sex positions. HRA attendance was significantly lower among persons living with HIV in the clinic arm compared to HIV-negative participants.
The model predicts that increasing PrEP coverage from 15% to 27% could avert 12.3% of HIV infections over 10 years, highlighting the interdependence of the interventions for maximal effectiveness.
High-risk alcohol use was associated with increased initiation of PrEP, with 35% of men in the high/very high-risk group starting PrEP compared to 18% in the no alcohol group. However, overall continuation of PrEP at 3 months was low, at only 30%.
FHS coverage was associated with a 24% reduction in AIDS incidence and a 32% reduction in mortality among low-income populations in Brazil, particularly benefiting individuals aged 35 and older.